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Thomas M. Polasek, Carl M. J. Kirkpatrick, and Amin Rostami-Hodjegan. Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation. Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers.

Translational Modelling in Drug Development. Articles Cited by Public access. Title. Sort. Sort by citations Sort by year Sort by title. 2018-03-27 Amin Rostami-Hodjegan's 405 research works with 11,975 citations and 7,405 reads, including: Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project Amin Rostami-Hodjegan's 43 research works with 197 citations and 1,933 reads, including: Scientific Considerations to Move Towards Biowaiver for BCS Class III Drugs:How Modeling and Simulation Can Amin Rostami-Hodjegan. Search for Amin Rostami-Hodjegan's work.

amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author 2011-11-01 Pris: 1769 kr.

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doi: 10.1208/s12248-016-9959-1. Review. PubMed PMID: 27506526. 11: Chen R, Rostami-Hodjegan A, Wang H, Berk D, Shi J, Hu P. Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6.

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Title: Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions VOLUME: 9 ISSUE: 5 Author(s):Jiansong Yang, Mingxiang Liao, Magang Shou, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU Professor Amin Rostami‐Hodjegan, PharmD, PhD, FCP, Centre for Applied Pharmaceutical Research, Manchester Pharmacy School, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E‐mail: amin.rostami@manchester.ac.uk. Search for more papers by this author Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology. Professor Rostami in 2007 at the University of Sheffield.

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Amin Rostami-Hodjegan's 43 research works with 197 citations and 1,933 reads, including: Scientific Considerations to Move Towards Biowaiver for BCS Class III Drugs:How Modeling and Simulation Can Amin Rostami-Hodjegan. Search for Amin Rostami-Hodjegan's work. Search Search. Home Amin Rostami-Hodjegan. Amin Rostami-Hodjegan. Skip slideshow.

J Clin Psychopharmacol 2004; 24: 70 –8. Jiansong Yang, Masoud Jamei, Amir Heydari, Karen R. Yeo, Rafael de la Torre, Magí Farré, Geoffrey T. Tucker, and Amin Rostami-Hodjegan Journal of Psychopharmacology 2006 20 : 6 , 842-849 Download Citation Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan, “ Prediction of Intestinal First-Pass Drug Metabolism”, Current Drug Kairui Feng1, Robert H. Leary1, Michael Dunlavey1, Amin Rostami-Hodjegan1,2 1. Certara, USA; 2. University of Manchester, UK; email: kevin.feng@Certara.com USP 1 USP 2 USP 3 USP 4 Figure 1. In Vitro dissolution profiles (n=3) of nifedipine IR capsule in FaSSGF.
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o, Igor Middel, Andries S. Koster, Find articles by 'Amin Rostami-Hodjegan' · Filter current search by 'Amin Rostami -Hodjegan' · Rostami-Hodjegan A. Find all citations in this journal (default). by Erik Mosekilde (Editor), Olga Sosnovtseva (Editor), Amin Rostami-Hodjegan ( Editor) & 0 more. ISBN-13: 978-3709104170. ISBN-10: 3709104173. Akira Takanaka; Akira Tsuji; Amin Rostami-Hodjegan; Chang.Koo Shim; Edmund JD Lee; Eiichi Fuse; Hideo Hakusui; Hidetoshi Yoshimura; Hideyuki Saito Thomas Hartung, Rex E FitzGerald, Paul Jennings, Gary R Mirams, Manuel C Peitsch, Amin Rostami-Hodjegan, Imran Shah, Martin F Wilks, Shana J Sturla. 2019年1月4日 Narciso Couto,Zubida M. Al-Majdoub,Brahim Achour,Phillip C. Wright,Amin Rostami-Hodjegan,Jill Barber. There is an urgent need (recognized 15 May 2017 in silico clinical trials of drug candidates.

Afternoon: Individual Arrival & Check-in at Marbach Castle: 03:00 p.m. Registration & Coffee: 04:00 … Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology.
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Multilevel-modeling, core predictions, and the concept of final

To investigate this apparent paradox, we evaluated omeprazole, esomeprazole, R -omeprazole, lansoprazole, and pantoprazole for their ability to function as amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author Amin Rostami-Hodjegan has filed for patents to protect the following inventions.

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Skip slideshow. Most frequent co-Author Amin Rostami-Hodjegan, Professor of Systems Pharmacology, University of Manchester Amin is a Professor of Systems Pharmacology at the Centre for Applied Pharmacokinetic Research (CAPKR) in the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester. He has an active program of training PhD students in Amin Rostami-Hodjegan talks with ScienceWatch.com and answers a few questions about this month's Fast Breaking Paper in the field of Pharmacology & Toxicology.: Article Title: Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Research Explorer. The University of Manchester's research has real-world impact beyond academia. We are at the forefront of the search for solutions to some of the world's most pressing problems, seeking to be a global force for positive change.

These may alter the exposure to xenobiotics between pregnant and non-pregnant women who receive similar doses, with implications for different susceptibility to environmental pollutants or therapeutic agents.